Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing
Figure 6
SARS-WT and S-ExoN1 titers across 20 population passages.
(A) Mean viral titers of three clones each of SARS-WT and S-ExoN1 at passages 1'-20'. Error bars indicate standard deviations. (B) Viral titers of individual clones of SARS-WT (closed symbols, solid lines) and S-ExoN1 (open symbols, dashed lines) at passages 1'-20'. At each passage Vero cells were infected at an MOI of 0.1 PFU/cell. Samples of culture medium were collected at 24 h p.i., titered by plaque assay at each passage, and transferred to naive cells.