Histone Deacetylases Play a Major Role in the Transcriptional Regulation of the Plasmodium falciparum Life Cycle
Figure 5
Inhibition of HDACs induces expression of transcription associated proteins.
A. Apicidin disrupts stage specific expression of the ApiAP2 proteins. B. Apicidin induces expression of transcription associated proteins. MOEs corresponding to individual genes and showing changes in gene expression and histone modifications induced by apicidin treatment are shown. The specific stage of expression, under normal developmental conditions, for each ApiAP2 protein is indicated on the right hand side. PfHDAC1 (PFI1260c), PfSir2 (PF13_0152), HDAC homologues (PF14_0489, PF14_0690 and PF10_0078), circumsporozoite protein (PFC0210c), erythrocyte binding antigen 175 (MAL7P1.176), apical membrane antigen 1 (PF11_0344), merozoite surface protein 6 (PF10_0346), ApiAP2 proteins (PF14_0633, PFF0200c, PF11_0404, PF14_0079, PF13_0097, PFL1075w, PF14 _0271, PFF1100c and PFD0200c), heterochromatin protein 1 (PFL1005c), Pfg27 (PF13_0011), Pfs16 (PFD0310w), Pfpeg-3 (PFL0795c), Pfpeg-4 (PF10_0164), Pf47 (PF13_0248), Pfg377 (PFL2405c), sporozoite surface protein 2 (PF13_0201), SPATR (PFB0570w), Pf52 (PFD0215c), PfGCN5 (PF08_0034), Pfactin 1 (PFL2215w) and PfMYST (PF11_0192).