Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo
Figure 1
Infection with SeV causes increased morbidity and mortality in MDA5−/− mice.
WT and MDA5−/− mice were infected with 200K pfu SeV and assessed for A) loss of body weight over the PI period and B) mucus production (PAS reactivity). C) WT and MDA5−/− mice were infected with 200K, 400K and 600K pfu SeV and assessed for viability. N = 4–16 mice, error bars refer to SEM, * P≤0.05.