Autocrine Production of β-Chemokines Protects CMV-Specific CD4+ T Cells from HIV Infection
Figure 5
MIP-1β producing pp65-specific CD4+ T cells have lower surface expression of CCR5.
A) pp65-specific CD4+ T cells which either produce or do not produce MIP-1β are overlaid onto a 2 dimensional histograph of memory CD4+ T cells plotted against CD57 and CCR5 surface expression for a representative HIV-uninfected and HIV-infected individuals. MIP-1β+ and MIP-1β− memory CD4+ T cells, shown by blue isobars, are overlayed on 2 dimensional density plots showing expression of CCR5 and CD57. B) For all seven of the non-HIV and all seven of the HIV infected individuals, pp65 specific CD4+ T cells which produced MIP-1β had lower MFIs for CCR5 surface expression than cells which did not produce MIP-1β (P<0.05).