Genes Selectively Up-Regulated by Pheromone in White Cells Are Involved in Biofilm Formation in Candida albicans
Figure 9
An updated model of the pathways regulating the pheromone-induced opaque (A) and white (B) responses that includes the downstream genes that are up-regulated through the opaque- and white-specific pheromone-response elements OPRE (A) and WPRE (B).
This model also includes genes that are up-regulated in both the opaque and white responses, and therefore contain both an OPRE and a WPRE in their promoters. The two pathways share the same components from receptor through the MAP kinase cascade [25]. However, there are two differences, circled in red. First, an extra region of the first intracellular loop (ICI) is essential for the white, but not the opaque response [26]. Second, the transcription factor targeted by the pathway is CPH1 in the opaque response and a still unidentified factor in the white response [25].