Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel
Figure 6
Binding of HMA to the ETM pentameric channel.
(A) Side view of the binding of HMA to the ETM pentamer in the vicinity of N15. The side chains of amino acids interacting with HMA are shown using a stick representation. (B) Binding of HMA to the C-terminal binding site of the channel, in the vicinity of T35 and R38. The lowest energy conformation of HMA is shown at the centre of bundle. For clarity, one of the ETM monomers has been removed. (C) and (D), top views of panels (A) and (B), respectively.