IP-10-Mediated T Cell Homing Promotes Cerebral Inflammation over Splenic Immunity to Malaria Infection
Figure 2
IP-10 neutralization alleviates brain intravascular infiltration.
P. berghei ANKA-infected mice were treated with anti-IP-10 or isotype control antibodies. (A) Pial microcirculation was examined by intravital microscopy on day 5 p.i.. The number of rolling (B) and adherent (C) cells was determined. Bars represent means of 4–5 mice±SEM, *p<0.05, **p<0.01 (Mann-Whitney test). C57BL/6 mice were infected with luciferase-expressing P. berghei ANKA and then treated with anti-IP-10 or isotype control antibodies. (D) Brain-sequestered parasites were visualized on day 6 p.i 1 h after luciferin injection. (E) Parasite-associated bioluminescence was determined. Bars represent means of 5 samples±SD.