Tentative T Cells: Memory Cells Are Quick to Respond, but Slow to Divide
Figure 2
The delay in naïve T cell division is organism-wide.
Mice containing approximately 1.4×105 CFSE-labeled SMARTA CD4+ T cells were infected with LCMV. At the indicated times after infection, lymphocytes were isolated (2 mice per time point) and the donor cells were identified by flow cytometry. A. The ovals in the dot plots identify the SMARTA CD4+ T cells, and the numbers indicate their percentage among leukocytes isolated from each tissue. The histograms show the CFSE-fluorescence of the SMARTA CD4+ T cells; the numbers indicate the percentages of SMARTA CD4+ T cells that have divided. B. The line graphs show the percentages of SMARTA CD4+ T cells among all isolated leukocytes at various times after infection. For each tissue, the dashed line indicates the number of SMARTA cells in uninfected mice.