Cationic Amino Acid Transporter-2 Regulates Immunity by Modulating Arginase Activity
Figure 6
Cytokine production and proliferation of CD4+ lymphocytes is impaired in the granulomatous tissues of infected CAT2−/− mice.
A. Leukocytes derived from the granulomatous livers of 8 wk infected WT C57BL/6 and CAT2−/− mice were stained with CFSE and cultured for 72 hrs in the presence of media alone or Con A (1 µg/ml). Cells were subsequently stained for IL-13 (left panels) and IFN-γ (right panels). Representative FACS plots are shown. The experiment was repeated numerous times with similar results. B. Mesenteric lymph node cultures from 8 wk S. mansoni infected WT and CAT2−/− mice.