Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1
Figure 6
No Support Maps: HLA-Associated Polymorphisms in Reverse Transcriptase, Vpr, and Nef That Do Not Map within Known or Putative Epitopes, and Are Not Supported by Functional IFN-γ (ELISpot) Data
Associations displayed on this map are likely to be highly enriched for the expected proportion of false-positives (20% with q < 0.2). However, we cannot rule out the possibility that these may represent processing escape mutations occurring distant from the epitope site, compensatory mutations, unusual epitopes, or other factors. Note that no “unsupported” HLA-associated polymorphisms were observed in HIV protease.