Roles of the Host Oxidative Immune Response and Bacterial Antioxidant Rubrerythrin during Porphyromonas gingivalis Infection
Figure 11
The Presence of the Rbr Gene Increases P. gingivalis–Induced Oral Bone Loss
Following a 10-d regimen of oral trimethoprim-sulfamethoxazole and a 3-d rest period, mice were administered 1.0 × 109 CFU of the P. gingivalis strains by oral gavage three times over a 1-wk period. One group of animals was not treated, and served as the age-matched controls. Six wk after oral challenge, all of the animals were killed. Linear bone loss measurements (n = 14) were obtained from the maxillary molars of each mouse, and the data for linear bone loss (in mm) from the cemento-enamel junction to the alveolar bone crest are presented as the means ± SEM of the pooled linear measurements obtained for each group. *p < 0.05; **p < 0.01; as determined by the Student's t test.