Dissecting the Origin of Breast Cancer Subtype Stem Cell and the Potential Mechanism of Malignant Transformation
Fig 4
Identification of origin-specific gene modules.
A, module 1 from luminal B CSC (left) and module 3 from bipotent-enriched progenitor cell (right). B, the result of functional enrichment analysis of module 1. The terms in red are related to mitochondrion. C, heat map of genes in module 1. Each row represents a gene; each column, a sample. Colored bar indicates the expression level. D, the result of prediction of transcription factor for module 1 by MatchTM. Each row represents a transcript. The number indicates the upstream distance from transcription start site.