Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I
Fig 2
Up- and Downregulated Gene Networks in IDUA-/- Canine Arteries.
Gene networks formed using GeneMania using the top related genes and at most 20 attributes. Interactions observed include co-expression, co-localization, genetic interactions, pathway, and physical interactions. A. Network of the upregulated genes. Notable genes in the upregulated network include lysosomal proteases (CTSB, CTSK, CTSS, LGMN); RRAGD, a GTPase involved in lysosomal energy sensing; immunity-related genes such as CD86 and BPI; and clusterin, a protein associated with atherosclerotic cardiovascular disease. B. Network of the downregulated genes. The notable genes in the downregulated network are primarily smooth muscle cytoskeletal elements (CNN1, DMD, MYH11, SMTH, TAGLN, TCAP, and TPN1).