Serological and Genetic Evidence for Altered Complement System Functionality in Systemic Lupus Erythematosus: Findings of the GAPAID Consortium
Fig 5
Association of organ involvement with ITGAM genotype and immune complex composition.
a. Percentage of the SLE patients with the involvement of the indicated three organs is shown for rs1143679 genotypes. The presence of single, double or triple organ involvement is illustrated by Euler ellipses with areas proportional to the percentages shown. b. Association with organ involvement of the level and composition (IgG, IgM, C4 and IgG/IgM) of immune complexes formed on dsDNA and nucleosome is indicated. Odds ratios for patients falling into the indicated percentile groups (upper 10th, 25th, 50th and lower 10th, 25th, 50th percentiles) for the given measurements are shown. Positive odds (>1) are in red, negative odds (<1) are in blue.