Immunisation With Immunodominant Linear B Cell Epitopes Vaccine of Manganese Transport Protein C Confers Protection against Staphylococcus aureus Infection
Fig 4
The survival rates of rMntC and peptides vaccine.
The survival rates of rMntC and conjunct peptides with KLH vaccine (with CFA/IFA as adjuvant), and CFA/IFA adjuvant alone as control, challenged for BALB/c mice (n = 10) by S. aureus strains MRSA252. The immunized dose of peptides vaccine was 40μl(100μg peptides-KLH) with 40μl CFA/IFA adjuvant and the mixture polypeptides vaccine was prepared with equal distribution of all three immunodominant epitopes (33.3μg/peptide-KLH) with 40μl CFA/IFA adjuvant. The survival rate comparison of rMntC and polypeptide vaccine were insignificant, but survival analyses and comparison of polypeptide vaccine and adjuvant control were significant when assessed by log rank test (P < 0.01).