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Genetic Evidence for Genotoxic Effect of Entecavir, an Anti-Hepatitis B Virus Nucleotide Analog

Fig 2

Entecavir induced the accumulation of γ-H2AX in nuclei of DT40 cells.

(A) Immuno-staining of wild-type (WT) and mutant DT40 clones using anti-γ-H2AX antibody and DAPI. Cells were fixed 6 hours after treated with entecavir 100nM. ETV, entecavir. (B) Quantification of γ-H2AX foci in individual cells of the indicated genotype. Cells were treated with entecavir 100nM for 6h. Data shown are the means of three experiments. Values shown are mean ± SD. ** P < 0.01, * P < 0.05 compared to WT. More than 100 cells were analyzed for each data point.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0147440.g002