Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation
Fig 9
A schematic diagram of curcumin-induced Akt degradation.
Autophagy is upregulated in curcumin-treated MDA-MB-231 breast cancer cells via an AMPK-mediated mechanism. The precise mechanism that regulates Akt ubiquitination and aggregation remains unclear; however, the presence of activated autophagy will result in degradation of the aggregated Akt leading to a reduction in Akt levels.