Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia
Fig 2
Functional recovery following ischaemia in ageing hearts.
Isolated hearts were perfused for 15 min at baseline, 15 min no flow ischaemia (grey) and 30 min reperfusion, when hearts from aged CrT-OE mice (n = 13) had improved functional recovery compared to aged WT hearts (n = 10). (a) rate pressure product, RPP; (b) left ventricular developed pressure, LVDP; (c) left ventricular systolic pressure, LVSP; (d) left ventricular end-diastolic pressure, LVEDP; (e) heart rate, HR. Data shown as mean values ± SEM. Comparisons between groups by two-way repeated measures (mixed model) ANOVA with a Bonferroni Post-hoc test. *P<0.05, **P<0.01, ***P<0.001