The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD
Fig 2
MIF and HIf-1α correlations in COPD and HIF-1 α regulation of Mif expression.
Correlation analysis between HIF-1α and MIF protein concentrations in isolated BAL macrophages from non-smokers (A), smokers (B), and COPD patients (C). Chromatin immunoprecipitation analysis of HIF-1α binding to HRE1 and HRE2 sites in the Mif promoter in mouse lung tissue (D). Data are expressed as mean±SD for 6 animals per group. **p<0.01 compared to air controls.