Hepatitis C Virus Increases Occludin Expression via the Upregulation of Adipose Differentiation-Related Protein
Fig 6
HCV increases occludin expression level via a mechanism dependent on ADRP.
Huh-7 were transfected with Jc1 RNA (HCV) and occludin mRNA (A) and protein (B-C) expressions were determined 48 h post transfection by RT-qPCR and immunoblotting respectively. (D) Control or ADRP-silenced cells were transfected or not with Jc1 full length RNA (HCV). Forty eight hours post infection, mRNA occludin level was determined by RT-qPCR. (E) Correlation between ADRP and occludin mRNA expression level in HCV infected patients (Table 1). Spearman’s r = 0.5236.