Recurrent Glioblastomas Reveal Molecular Subtypes Associated with Mechanistic Implications of Drug-Resistance
Fig 3
Expression of stemness-like traits in G1 recurrent tumors.
(A) Network analysis using G1 signature genes reveals the CDK and AURK as the key hub genes (top). Pathway (light blue) and physical interactions (light pink) are indicated with different colors. The heatmap of the expression of the key hub genes (CDK1, AURKA, AURKB, HMMR, RAD45L) are plotted (bottom) (B) The GSEA result show the enrichment of the ES1 signature (top) and the expression of the top 20 differentially expressed genes are shown (bottom) (C) The plots showed the enrichment scores (ES) for the HOX_GENE signature (top) and their expression heatmap is shown (bottom). (D) The expression of HOX10a in G1 and G2 tumors are plotted. Statistical significance is calculated using Welch Two Sample T-test.