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Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells

Fig 6

Role of hsa-miR-663b in IL21-mediated gene regulation.

The box plots indicate the expression of CCL17, DDR1, CD40 and PIK3CD genes in CLL cells from five different patients transfected with an irrelevant RNA sequence (indicated as irr) or with hsa-miR-663b (indicated as 663b). In addition, IL21-stimulated CLL cells were transfected with the irrelevant RNA (indicated as irr IL21) or with hsa-miR-663b antagonist (indicated as a663b IL21). Expression was tested by RT-qPCR. Statistical analysis was performed using the Kruskall—Wallis test.

Fig 6

doi: https://doi.org/10.1371/journal.pone.0134706.g006