Soybean Oil Is More Obesogenic and Diabetogenic than Coconut Oil and Fructose in Mouse: Potential Role for the Liver
Fig 11
Hepatic metabolite levels change with diet and over time.
Box-plots of liver metabolomics data from male mice fed the indicated diets for 16 or 35 weeks showing changes in levels of A) Linoleic acid, B) Arachidonic acid, C) 12-HETE, D) 13 HODE +9 HODE, E) Glutathione, oxidized, F) γ-Tocopherol, G) α-Tocopherol, H) 3-Hydroxybutyrate, I) Lactate, and J) Cholesterol. At 16 weeks SO-HFD is significantly different from HFD for all metabolites except γ-tocopherol, lactate and cholesterol. At 35 weeks there is no statistical difference between SO-HFD and HFD except for linoleic acid, γ-tocopherol and lactate; cholesterol is approaching significance. Significance, P ≤ 0.05; approaching significance, 0.05 < P < 0.10 by Welch’s two sample t-test. (See S4 Dataset for additional box plots.)