C6 Peptide-Based Multiplex Phosphorescence Analysis (PHOSPHAN) for Serologic Confirmation of Lyme Borreliosis
Fig 4
Sensitivity of PHOSPHAN tests for serum IgG antibody responses to B. burgdorferi C6, B. garinii C6, and B. afzelii C6 in samples from EM patients.
(A) Total sensitivity of PHOSPHAN variants G1, G2, G3, and G1–3 at the baseline prior to treatment (N = 146). (B) Sensitivity of PHOSPHAN variants G1–G3 in tests of samples taken at the baseline (n = 146) and on days 8–14 (n = 75), 15–30 (n = 48), and 31–66 (n = 82) after disease onset. Values that are statistically significant (Fisher's exact test, p < 0.05) are denoted by brackets or asterisks. Immunoassay codes: G1, Bb C6 IgG; G2, Bg C6 IgG; G3, Ba C6 IgG; G1–3, any of the three antigens Bb C6, Bg C6, or Ba C6. (Bb) B.burgdorferi, (Bg) B.garinii, (Ba) B.afzelii. Legend: (B) Transparent square, G1; Black diamond, G2; Black triangle, G3.