Pandemic Swine-Origin H1N1 Influenza Virus Replicates to Higher Levels and Induces More Fever and Acute Inflammatory Cytokines in Cynomolgus versus Rhesus Monkeys and Can Replicate in Common Marmosets
Fig 2
Virus replication in cynomolgus macaques and rhesus macaques after Mex4487 influenza virus infection.
Virus load measured by RT-PCR in tracheal swabs, nose swabs and serum in time and in bronchoalveolar lavage (BAL) fluid taken just before necropsy; i.e. at day 3, 6 and 14 in two animals each time, measured in cynomolgus and rhesus monkeys. Colors in the BAL bar graphs correspond to colors in the line graphs. P = 0.004: statistically significant difference in virus load in tracheal swab. Viral load was calculated for each animal as area under the curve (AUC). For statistical analysis the AUC in six cynomolgus macaques were compared with six rhesus macaques (Mann-Whitney test).