Stromal Transcriptional Profiles Reveal Hierarchies of Anatomical Site, Serum Response and Disease and Identify Disease Specific Pathways
Fig 1
Identification of a hierarchy of molecular signatures in arthritis derived fibroblasts.
The relative similarity of the different groups of fibroblast in a principal component (PC) plot is shown. Groups defined by disease state and anatomical location are indicated by coloured symbols whereas individual samples response to serum (Hi, High serum; Lo, low serum) is shown by a solid grey line. The PCA clearly separates synovium (Syn, red and orange) from bone marrow (BoM, blue and grey) and skin (Skn, green and light blue) on the first PC. Skin and bone marrow samples are only separated on the second PC. Additionally it can be observed that all samples are separated by their serum response mainly on the first PC.