Sporadic Premature Aging in a Japanese Monkey: A Primate Model for Progeria
Figure 4
Shrinkage of the cerebral cortex and the hippocampus in monkey N416 was revealed with MRI.
A,C,D: Parasagittal images of monkey N416 (1 year and 5 months old), an age-matched control, and an aged monkey (28 years old), respectively. Note that expansion of the cerebral sulci (arrows) in monkey N416 is as large as and expansion of the lateral ventricles (arrowheads) is larger than those in the aged monkey. This is probably ascribed to shrinkage of the cerebral cortex and the hippocampus. B: Coronal image of monkey N416. Seen is prominent expansion of the lateral ventricles (arrowheads).