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c-Src Binds to the Cancer Drug Ruxolitinib with an Active Conformation

Figure 1

Structure of c-Src in complex with Ruxolitinib.

(A) Overall structure of c-Src/Ruxolitinib complex. (B) The pyrrolopyrimidine rings form two hydrogen bonds with the main chain atoms of Met341. (C) Ruxolitinib forms a water-mediated interaction with Src gatekeeper residue Thr338.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0106225.g001