Signaling Networks Converge on TORC1-SREBP Activity to Promote Endoplasmic Reticulum Homeostasis
Figure 10
A number of major signaling pathways, including a core module regulating G1/S transition in proliferating cells, converges on TORC1/SREBP signaling to regulate ER homeostasis.
The figure shows a graph depicted after Hierarchical Interaction Score analysis of the phenotypes displayed by ER homeostasis regulators across functional assays. The direction of each edge represents functional dependencies, and the thickness of each line defines the strength of each dependency. Nodes are coloured based on the proteins known function or physiological role as follows: blue = regulators of growth; red = regulators of cell-cycle progression; green = ER proteins; yellow = regulators of transcription/translation; grey = regulators of lipid metabolism; pink = stress response proteins; white = general signaling proteins.