Manganese-Induced Atypical Parkinsonism Is Associated with Altered Basal Ganglia Activity and Changes in Tissue Levels of Monoamines in the Rat
Figure 3
Manganese progressively reduced exploratory activity.
Exploratory activity histograms represent the number of horizontal (A), stereotypic (B), and vertical movements (C) recorded during the first session of 10 min in the “open field” actimeter before and during all period of treatment. Values are the mean ± SEM. Data from manganese-treated rats (n = 12) and controls (n = 11) were compared using the two way repeated measures ANOVA and Holm-Sidak post hoc. *p<0.05, **p<0.01.