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Hard-Diet Feeding Recovers Neurogenesis in the Subventricular Zone and Olfactory Functions of Mice Impaired by Soft-Diet Feeding

Figure 3

Fos-ir cells after exposure to urinary odor in the OB and Pir.

Sagittal sections of the OB and Pir after exposure of mice fed only a hard diet (A and E), only a soft diet (B and F), or a hard diet for 3 months after a soft diet for 1 month (C and G) to urinary odor, respectively. Scale bar: 200 µm (C), 500 µm (G). D: The numbers of Fos-ir cells in the mitral cell layer in 500 µm thickness from Figure 108 of the mouse atlas (lateral 0.84 mm) of the OB to the lateral side of mice fed only the hard diet (black column; n = 5), only the soft diet (white column; n = 5), or the hard diet after the soft diet (gray column; n = 5). H: The number of Fos-ir cells in 400 µm thickness from Figure 114 of the mouse atlas (lateral 1.56 mm) of the Pir of mice fed only the hard diet (black column; n = 5), only the soft diet (white column; n = 5), or the hard diet after the soft diet (gray column; n = 5). *: p<0.05; **: p<0.005.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0097309.g003