Digital Expression Profiling Identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as Potential Predictive Biomarkers for Neo-Adjuvant Chemotherapy Response in Paediatric Osteosarcoma
Figure 1
Cluster map constructed using Cluster 3.0, showing the differential expression of the 17 gene set in osteosarcoma biopsy and resection cases in the cohort.
Patients with >90% tumor necrosis in response to chemotherapy (good response) are shown in blue and those with <90% (poor response) are shown in red. Sample numbers 1–36 were analyzed in triplicates whereas samples 41–116 were analysed in duplicates. Detailed data manipulation for the cohort is presented in Table S2B.