Effects of Calorie Restriction and Diet-Induced Obesity on Murine Colon Carcinogenesis, Growth and Inflammatory Factors, and MicroRNA Expression
Figure 3
Tumor multiplicity among CR, control, and DIO mice.
The total number of tumors was counted along the entire length of the colon after methylene blue staining. Bars represent the average number of tumors per colon in all three dietary groups (n = 12 at 5 weeks, n = 12 at 10 weeks, n = 20 at 20 weeks). Five weeks, one-way ANOVA, p = 0.63. Ten weeks, one-way ANOVA, p = 0.01. Twenty weeks, one-way ANOVA, p = 0.0001. a and b represent dietary treatments that are significantly different from one another (p = 0.009) as determined by Bonferroni test. c, d, and e represent dietary treatments that are significantly different from one another (p<0.05) as determined by Bonferroni test.