A Cannabigerol Derivative Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis
Figure 4
VCE-003 alleviates EAE and prevents CD4+ cells infiltration.
(A) VCE-003 significantly ameliorates the clinical signs and disease progression of EAE (squares), and these effects are partially blocked by a CB2 antagonist (AM630, triangles) or PPARγ antagonist (T0070907, circles). The results are shown as the means ± SD: *p = 0.015 EAE + VCE-003 vs EAE + VEH; **p = 0.005 EAE + VCE-003 vs EAE + VEH; ***p<0.001 EAE + VCE-003 vs EAE + VEH; #p = 0.016 EAE + VCE-003 + AM630 vs EAE + VCE-003; ##p = 0.008 EAE + VCE-003 + AM630 vs EAE + VCE-003; ###p<0.001 EAE + VCE-003 + AM630 vs EAE + VCE-003; +p = 0,009 EAE + VCE-003 + T0070907 vs EAE + VCE-003; ++p<0.01 EAE + VCE-003 + T0070907 vs EAE + VCE-003. (B) VCE-003 reduces the number of infiltrates and (C) it significantly reduces the number of CD4+ T cells in thoracic spinal cord sections. The figure shows the representative staining of spinal cord sections: LFB (B) and CD4 immunohistochemistry (C). Arrows indicate CD4+ T cells. The results (C) are shown as the means ± SEM: **p = 0,004 vs Intact; #p = 0,030 vs EAE + VEH.