Tissue Specific DNA Methylation in Normal Human Breast Epithelium and in Breast Cancer
Figure 5
TRIM29 gene expression and promoter methylation varies in breast cancer subtypes.
Analysis of TCGA data base shows (A) variable gene expression of TRIM29 in normal breast tissues (n = 97) and in breast tumor subtypes defined by the PAM50 classification: basal (n = 75), luminal A (n = 187), luminal B (n = 104), HER2 (n = 46), normal-like (n = 6). Heat map scale ranges from red (high) to green (low). (B) Variable methylation at the promoter of TRIM29 (Illumina probe #cg13625403) in breast tumor subtypes. Expression inversely correlates with promoter methylation. Data was selected from TCGA data base as described in methods. Number of samples indicated at the bottom, ***p<0.001, *p<0.01, P-values between groups were calculated using Welch's corrected t-test.