Quantitative Analysis of the Anti-Proliferative Activity of Combinations of Selected Iron-Chelating Agents and Clinically Used Anti-Neoplastic Drugs
Figure 4
Combinations of NHAPI or its Fe complex with TMX in MCF-7 cells behave synergistically.
The combination index-cellular proliferation dependency was calculated using CalcuSyn 2.0 software. These studies were performed using 72 h incubations of the studied agents at concentrations corresponding to the various IC50 multiples and fractions; CI <1, ≈1, or >1 indicate synergism, an additive effect, or antagonism, respectively. Results are means of n≥4 experiments.