Quantitative Trait Loci Affecting Atherosclerosis at the Aortic Root Identified in an Intercross between DBA2J and 129S6 Apolipoprotein E-Null Mice
Figure 2
Genome-wide single QTL scans for atherosclerotic plaque size at the root.
(A) LOD curves for the root lesion with sex as an additive covariate (black line) and as an interactive covariate (red line). X-axis represents positions on chromosome (cM) and y-axis represents the LOD score. The horizontal dashed lines represent the thresholds for significant QTL (p = 0.05) and suggestive QTL (p = 0.63) in the sex-interactive model. (B) Differences in LOD curves of the sex-additive model and the sex-interactive model (LODi). (C) LOD curves for root lesion in males (blue line) and females (red line). The horizontal dashed lines represent the thresholds for significant QTL (p = 0.05) and suggestive QTL (p = 0.63) in males (blue) and females (red). The arrow indicates the second QTL on Chr 1 in females.