Ectopic Cerebellar Cell Migration Causes Maldevelopment of Purkinje Cells and Abnormal Motor Behaviour in Cxcr4 Null Mice
Figure 4
Cxcr4 deficiency results in ectopic granule cells, Purkinje cells, and disorganized axon projections in adult mice.
(A,B) The NeuN staining in adult cerebellum revealed granule cells ectopia and absent cerebellar lobules. (C.D) Calbindin staining reveals disorganized Purkinje cells and reduced dendritic elaboration. (E.F) Myelinated axon fibers, shown via a stain against CNPase, are disorderly in KO mice. Scale bar = 200 µm.