Molecular Characterization of Antigen-Peptide Pulsed Dendritic Cells: Immature Dendritic Cells Develop a Distinct Molecular Profile when Pulsed with Antigen Peptide
Figure 2
Supervised Hierarchical Clustering Analysis (HCA) presenting a set of significant 59 genes that distinguished three differentiation stages of DCs: piDC (G1), iDC (G3) and mDC (G5).
Microarray data of piDC, iDC and mDC from donor D1–D4 were analyzed by ANOVA. Significant genes among the three stages were selected using the criteria set at p-value<0.05 and fold change ≥1.5. Genes with F-ratio>4.7 were presented. Color indicator shows log2 value of the intensity of sample against MonoRef.