Robust Prognostic Gene Expression Signatures in Bladder Cancer and Lung Adenocarcinoma Depend on Cell Cycle Related Genes
Figure 3
Prognostic value of cell cycle proliferation (CCP) gene score in bladder cancer and lung adenocarcinoma.
A, prognostic value of CCP score for progression in bladder cancer in the CNUH (N = 165), Lindgren (N = 97), and Dyrskjot (N = 353) cohorts. In the CNUH and Lindgren cohorts, follow-up time was not available so we evaluated the ability of CCP score to discriminate between non-progressors (NP) and progressors (P) as described in Materials and Methods. In the Dyrskjot cohort, Kaplan-Meier (KM) curves for progression-free survival (PFS) were generated for patients with CCP scores at the lower (green), middle (blue), and upper (red) 33% and the log rank P-value of the continuous CCP score is reported. B, prognostic value of CCP score for survival in bladder cancer. KM curves were generated as in (A) for overall survival (OS) in the Blaveri (N = 74) cohort and for disease-specific survival (DSS) in the CNUH (N = 165), Dyrskjot (N = 366), Lindgren (N = 142), and MSKCC (N = 87) cohorts. C, prognostic value of CCP score for survival in lung adenocarcinoma. KM curves were generated for OS or recurrence-free survival (RFS) in the CAN/DF (N = 82), MSK (N = 104), Son (N = 62), Takeuchi (N = 90), and Tomida (N = 117) cohorts. Abbreviations: HR, hazard ratio, corresponding to 1-unit increase in CCP score.