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Wound Healing Improvement with PHD-2 Silenced Fibroblasts in Diabetic Mice

Figure 4

Wound healing of the diabetic wound.

A: Gross imaging of the wound healing. The wounds in group 2 healed within 2 weeks. The wound healing in group 3, which was implanted with fibroblasts treated by L-mimosine, was also accelerated when compared with the rest three groups. B: Wound closure quantified. The time to wound closure in group 1 (implanted with untreated fibroblasts ) was around 21 days. In group 2 (implanted with PHD2 siRNA treated fibroblasts), the time was shortened to less than 2 weeks with statistic significance (p≤0.05). The time in group 3 (implanted with L-mimosine treated cells) was around 18 days (P≤0.05). In group 1 and group 4, the wounds healed in 3 weeks. In group 5(sham control group), the wounds needed nearly 4 weeks to heal.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0084548.g004