Role of miR-17 Family in the Negative Feedback Loop of Bone Morphogenetic Protein Signaling in Neuron
Figure 6
Schematic diagram of a negative regulatory loop of BMP-miR-17 family-BMPRII.
BMPs activate Smads via BMPRI-II complex, leading to the increase of miR-17 family, which represses BMPRII expression to prevent aberrant activation of this signaling pathway.