Machine-Based Morphologic Analysis of Glioblastoma Using Whole-Slide Pathology Images Uncovers Clinically Relevant Molecular Correlates
Figure 6
Estimated probability density functions associated with means of eccentricity and circularity.
Estimated probability density functions associated with means of eccentricity and circularity demonstrate significant differences between (A-B) HOC 0+1 and HOC 2; and (C-D) MOC 0+1 and MOC 2 groups. Note that the probability density function of eccentricity average presents lower population mean for OC 2 group and higher mean for OC 0+1 group. Similarly, the probability density function of circularity average presents higher population mean in the OC 2 group and lower mean for OC 0+1 group. The findings agree with the domain knowledge of oligodendroglioma and astrocytoma nuclear morphology.