Changes in Sensitivity of Reward and Motor Behavior to Dopaminergic, Glutamatergic, and Cholinergic Drugs in a Mouse Model of Fragile X Syndrome
Figure 4
Effects of the mGluR5-selective antagonist MPEP on ICSS and locomotor behavior in wild type (WT, white circles) and Fmr1-/Y mice (red circles).
Changes in BSR threshold (A) and maximum operant response rate (MAX, B) 31-45 minutes after i.p. MPEP injections are shown. Values are expressed as mean percentages of pre-injection baselines ± SEM.
Asterisks (*) indicate p < 0.05 vs. vehicle (V); daggers (†) indicate p < 0.05 vs. WT (dose x genotype interaction post hoc). C. Mean distance traveled (± SEM) before and after injection of saline (VEH) or MPEP (5.6 mg/kg i.p.) in 15-minute intervals. Shading indicates post-injection time points. Daggers (†) indicate p < 0.05 vs. WT (time x genotype interaction post hoc). D. Mean change in locomotion (± SEM) as a percentage of pre-injection baseline for 60 minutes after injection of saline (VEH) or MPEP (5.6 mg/kg i.p.).