A Small Volatile Bacterial Molecule Triggers Mitochondrial Dysfunction in Murine Skeletal Muscle
Figure 2
2-AA treatment differentially modulates the genes involved in energy production and intermediate metabolism in skeletal muscle.
Differentially expressed genes involved in energy production (A) and intermediate metabolism (B) in response to 2-AA treatment. Grey boxes represent up–egulation, and black boxes represent down-regulation, of the respective gene in muscle from 2-AA treated versus control mice. The negative log10 of p-values represented by gray triangles are shown in the right vertical axis. The expression of certain key genes is down-regulated, consistent with the in vivo 31P-NMR data (Figure 1 and Table 2).