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High Antibody Responses against Plasmodium falciparum in Immigrants after Extended Periods of Interrupted Exposure to Malaria

Figure 3

IgG antibody responses to merozoite antigens (A) and P. falciparum Infected Erythrocytes (B) in immigrants (Immigr) and travelers (Trav) with clinical malaria.

IgG levels were determined at the acute episode of malaria (day 0, black boxes) and at convalescence (day 7, white boxes). Data are presented as boxplots that illustrate the medians and the 25th and 75th quartiles, and the whiskers represent the 10% and 90% percentiles. Outliers are marked with circles. P-values were calculated using the Wilcoxon Rank Sum test. Cutoff values for seroprevalences were 238.02 AU for AMA-1 3D7, 1134.73 AU for AMA-1 FVO, 921.18 AU for MSP-142 3D7, 638.33 AU for MSP-142 FVO,3110.36 AU for EBA-175, 1572.55 AU for DBL-α, 36.88 MFI for IETrav1, 38.55 MFI for IETrav2, 24.75 MFI IETrav3, 14.23 MFI for CS2, 19.92 MFI for R29, 8.69 MFI for ECh1, 1.98 MFI for IECh2, and 5.54 MFI for IEWoman.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0073624.g003