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Baicalein Reduces Airway Injury in Allergen and IL-13 Induced Airway Inflammation

Figure 1

Effect of Baicalein (BAIC) pretreatment on airway hyperresponsiveness (AHR) to Methacholine.

A) Male Balb/c mice were sensitized and challenged as shown. AHRs were determined on Day 33. B) In dose titration experiments, single chamber plethysmography results were expressed as MCh PC200 [the partial concentration of methacholine which is required to double the baseline enhanced pause (Penh)]. C) In preventive model, invasive airway mechanics results were expressed as airway resistance. D) Representative photomicrographs of Haematoxylin and Eosin staining were shown. Br, bronchus; V, vessel; a, alveolus; Image are shown at 20X magnifications. E) Absolute cell count in BAL fluid. Absolute number of eosinophils (Eosino), macrophages (Macro), mononuclear agranulocytes (Mono), and neutrophils (Neutro) in BAL fluid was determined as described in Materials and Methods. Data were mean ± SEM. *P<0.05 vs. SHAM/PBS/VEH and P<0.05 vs. OVA/OVA/VEH; n = 5–6 mice in each group.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0062916.g001