Hydrogen Peroxide Produced by Oral Streptococci Induces Macrophage Cell Death
Figure 7
Induction of TNF-α by S. oralis spxB KO mutant.
Differentiated THP-1 macrophages were infected with viable S. oralis strains for 2 h, and then washed and cultured for additional 18 h. Other cultures were stimulated by exposure to H2O2. The release of TNF-α was determined using an ELISA kit. Data are shown as the mean ± SD of triplicate samples. *p<0.05 as compared with untreated control (None).