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In Vivo Intracellular Oxygen Dynamics in Murine Brain Glioma and Immunotherapeutic Response of Cytotoxic T Cells Observed by Fluorine-19 Magnetic Resonance Imaging

Figure 1

In vitro calibration curve for R₁ = 1/T₁ versus pO₂.

Here, solid circles represent average ¹⁹F R₁ measurements of six oxygen partial pressure values, each in triplicate, ranging from 0% to 100% oxygen in a saturated O₂/N₂ mixture of PFC emulsion in water. The solid line is the calibration curve fit by the linear least squares method (R² = 0.99). Data were collected at 11.7 T and 37°C. 100% oxygen is equivalent to 760 mm Hg. (The R₁ error bars are smaller than the point size.)

doi: https://doi.org/10.1371/journal.pone.0059479.g001