Time Courses of Changes in Phospho- and Total- MAP Kinases in the Cochlea after Intense Noise Exposure
Figure 7
Summary of upregulation of MEK1/ERK1/2/p90 RSK, JNK/c-Jun and p38 MAPK in the cochlea after exposure to the intense noise.
The phospho-MEK1/ERK1/2/p90 RSK signaling pathway was activated in the spiral ligament and in the sensory and supporting cells of the organ of Corti, with peaks at 3–6 h and independently of de novo synthesis of the protein kinases. The expression of phospho-JNK and p38 MAPK showed late upregulation in the spiral neurons at 48 h, in addition to early upregulation with peaks at 3 h after the noise trauma. Phospho-p38 MAPK and c-Jun activation was dependent on de novo synthesis of the proteins.